Your brain-injured client may have hypopituitarism. Here’s why that’s important.

Your brain-injured client may have hypopituitarism. Here’s why that’s important.

As discussed in a recent webinar, hypopituitarism is a commonly under-diagnosed complication in traumatic brain injury (TBI) cases. Many medical evaluations miss this devastating condition, as symptoms of hypopituitarism mimic those of other TBI symptoms. These can include fatigue, sleep disturbances, anxiety, depression, lack of motivation and/or impairment of cognitive function. If left untreated, hypopituitarism can have a significant effect on your client’s life.

Recent studies show patient improvement with the use of growth hormone replacement therapy. Diagnosis must come before treatment, however; for attorneys representing clients living with TBIs, consider that hypopituitarism be evaluated prior to settlement negotiations. Growth-hormone replacement therapy — while costly — can provide a tremendous improvement in your client’s quality of life.

To learn more about this under-diagnosed condition, check out the recent Trial Guides webinar with Dr. Randall Benson, Pituitary Dysfunction After Traumatic Brain Injury. Here are some other studies that discuss this topic:

Studies Referenced

  • Effect of growth hormone replacement therapy on cognition after traumatic brain injury


  • Growth Hormone Alters Brain Morphometry, Connectivity, and Behavior in Subjects with Fatigue after Mild Traumatic Brain Injury
    • Traver Wright 1 2, Randall Urban 1, William Durham 1, E Lichar Dillon 1, Kathleen M Randolph 1 2, Christopher Danesi 1, Charles Gilkison 1, Christof Karmonik 3, Dennis J Zgaljardic 4, Brent Masel 5, James Bishop 6, Richard Pyles 7, Rachael Seidler 8, Ashton H Hierholzer 9, Melinda Sheffield-Moore 1 2 


  • Effects of growth hormone (GH) replacement and cognitive rehabilitation in patients with cognitive disorders after traumatic brain injury


  • Growth hormone replacement therapy in patients with traumatic brain injury



  • The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: a meta-analysis of the current literature